Evaluation of Amantadine in the Prophylaxis of Influenza A (H1N1) Virus Infection: A Controlled Field Trial among Young Adults and High-Risk Patients
Identifieur interne : 002814 ( Main/Exploration ); précédent : 002813; suivant : 002815Evaluation of Amantadine in the Prophylaxis of Influenza A (H1N1) Virus Infection: A Controlled Field Trial among Young Adults and High-Risk Patients
Auteurs : R. F. Pettersson [Finlande] ; P.-E. Hellström [Finlande] ; K. Penttinen [Finlande] ; R. Pyh L [Finlande] ; O. Tokola [Finlande] ; T. Vartio [Finlande] ; R. Visakorpi [Finlande]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1980.
Abstract
The usefulness of amantadine in the protection of humans against influenza A (H1N1) virus was evaluated in a double-blind field trial with 555 volunteers in Finland in the winter of 1978. Three populations—patients in a general hospital, adults in a home for the aged, and two groups of military conscripts-were chosen. Epidemic influenza occurred only in the two groups of conscripts: the incidence of serologically verified influenza was 66% and 83% in the groups that received placebo and 43% and 51% in the groups that received amantadine, giving protection rates of 36% (P = 0.05) and 39% (P = 0.001). The evaluation of the effect of amantadine on the occurrence of illness was obscured by concomitant adenoviral infections that caused influenza-like symptoms. No clear difference in the occurrences of side effects was observed between the placebo and amantadine-treated groups; however, a significantly greater number of participants who took 200 mg of amantadine/day (16.9%) stopped medication during the trial as compared with the placebo groups (7.6%) (P < 0.02).
Url:
DOI: 10.1093/infdis/142.3.377
Affiliations:
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<front><div type="abstract">The usefulness of amantadine in the protection of humans against influenza A (H1N1) virus was evaluated in a double-blind field trial with 555 volunteers in Finland in the winter of 1978. Three populations—patients in a general hospital, adults in a home for the aged, and two groups of military conscripts-were chosen. Epidemic influenza occurred only in the two groups of conscripts: the incidence of serologically verified influenza was 66% and 83% in the groups that received placebo and 43% and 51% in the groups that received amantadine, giving protection rates of 36% (P = 0.05) and 39% (P = 0.001). The evaluation of the effect of amantadine on the occurrence of illness was obscured by concomitant adenoviral infections that caused influenza-like symptoms. No clear difference in the occurrences of side effects was observed between the placebo and amantadine-treated groups; however, a significantly greater number of participants who took 200 mg of amantadine/day (16.9%) stopped medication during the trial as compared with the placebo groups (7.6%) (P < 0.02).</div>
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<name sortKey="Vartio, T" sort="Vartio, T" uniqKey="Vartio T" first="T." last="Vartio">T. Vartio</name>
<name sortKey="Visakorpi, R" sort="Visakorpi, R" uniqKey="Visakorpi R" first="R." last="Visakorpi">R. Visakorpi</name>
<name sortKey="Visakorpi, R" sort="Visakorpi, R" uniqKey="Visakorpi R" first="R." last="Visakorpi">R. Visakorpi</name>
<name sortKey="Visakorpi, R" sort="Visakorpi, R" uniqKey="Visakorpi R" first="R." last="Visakorpi">R. Visakorpi</name>
<name sortKey="Visakorpi, R" sort="Visakorpi, R" uniqKey="Visakorpi R" first="R." last="Visakorpi">R. Visakorpi</name>
<name sortKey="Visakorpi, R" sort="Visakorpi, R" uniqKey="Visakorpi R" first="R." last="Visakorpi">R. Visakorpi</name>
<name sortKey="Visakorpi, R" sort="Visakorpi, R" uniqKey="Visakorpi R" first="R." last="Visakorpi">R. Visakorpi</name>
</country>
</tree>
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